Generation of personalized tumor Biopsy-Derived Natural Killer (BDNK) cells.
نویسندگان
چکیده
منابع مشابه
Optimized protocols for generation of cord blood-derived cytokine-induced killer/natural killer cells.
The efficacy of various combinations of stem cell factor (SCF), FLT3 ligand, interleukin (IL)-2, IL-7 and IL-15 to induce and expand cord blood-derived cytokine-induced killer (CIK) cells was investigated. There were three treatment groups: group A: SCF combined with IL-2, IL-7 and IL-15; group B: SCF, FLT3 ligand combined with IL-2, IL-7 and IL-15, and group C: IL-2, IL-7 and IL-15, the contro...
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How myeloid-derived suppressor cells (MDSC) emerge in the tumor environment remains unclear. Here, we report that GM-CSF can convert natural killer (NK) cells into MDSCs. When transferred into tumor-bearing mice, adoptively transferred NK cells lost their NK phenotype and were converted into Ly6C(high)Ly6G(high) MDSC. This conversion was abolished by exposure to IL-2 either in vitro or in vivo....
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Background: Schizophrenia has been associated with altered immunity. Different studies regarding natural killer cell activity (NKA) in schizophrenic patients have shown inconsistent results. Objectives: To evaluate NK cell activity in schizophrenic patients in comparison with healthy control individuals. Methods: 30 medication-free schizophrenic patients and 41 healthy sex, age and smoking st...
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objective: adipose derived stem cells (ascs), as one of the important stromal cells in the tumor microenvironment, are determined with immunomodulatory effects. the principle aim of this study was to evaluate the immunosuppressive effects of ascs on natural killer (nk) cells. materials and methods: in this experimental study, we assessed the expressions of indolamine 2, 3-dioxygenase (ido1), id...
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PURPOSE Increased frequencies of myeloid-derived suppressor cells (MDSC) correlate with poor prognosis in patients with cancers. Tumor-derived prostaglandin-E2 (PGE2) plays an important role in inducing MDSCs. However, the detailed mechanisms of this induction remain unknown. To develop targeted therapies for MDSCs, we sought to investigate the molecular basis of PGE2-regulated accumulation of ...
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ژورنال
عنوان ژورنال: Journal of Global Oncology
سال: 2019
ISSN: 2378-9506
DOI: 10.1200/jgo.2019.5.suppl.86